Staphylococcal enterotoxin C2 promotes osteogenesis.....

2020-12-02 09:35:02

Staphylococcal enterotoxin C2 promotes

osteogenesis of mesenchymal stem cells

and accelerates fracture healing


As one of the heat-stable enterotoxins, Staphylococcal enterotoxin C2 (SEC2) is synthesized

by Staphylococcus aureus, which has been proved to inhibit the growth of tumour cells, and

is used as an antitumour agent in cancer immunotherapy. Although SEC2 has been reported

to promote osteogenic differentiation of human mesenchymal stem cells (MSCs), the in vivo

function of SCE2 in animal model remains elusive. The aim of this study was to further elucidate

the in vivo effect of SCE2 on fracture healing.

Materials and Methods

Rat MSCs were used to test the effects of SEC2 on their proliferation and osteogenic differentiation

potentials. A rat femoral fracture model was used to examine the effect of local

administration of SEC2 on fracture healing using radiographic analyses, micro-CT analyses,

biomechanical testing, and histological analyses.


While SEC2 was found to have no effect on rat MSCs proliferation, it promoted the osteoblast

differentiation of rat MSCs. In the rat femoral fracture model, the local administration of

SEC2 accelerated fracture healing by increasing fracture callus volumes, bone volume over

total volume (BV/TV), and biomechanical recovery. The SEC2 treatment group has superior

histological appearance compared with the control group.


These data suggest that local administration of SEC2 may be a novel therapeutic approach

to enhancing bone repair such as fracture healing.

Cite this article: Bone Joint Res 2018;7:179–186.

骨与关节研究杂志   2018




香港中文大学 李刚










Staphylococcal enterotoxin C2 promotes  osteogenesis of mesenchymal stem cells  and accelerates fracture healing.pdf